What are off episodes?

The "OFF" phenomenon in PD refers to the phase of immobility in Levodopa-treated patients, which occurs as an end-of-dose worsening of motor functions

"OFF" episodes can happen when:

  • Your oral Levodopa medication effect has worn-off
  • "OFF" episodes are common in PD and can happen at any time
  • Your "OFF" episode may consist of difficulty moving or walking, tremor, trouble getting around, slowness, and stiffness
  • May last for a few minutes or up to a few hours
  • May be experienced multiple times a day


Of patients experience OFF episodes after they have been taking Levodopa for

4 to 6 years9


Of patients experience OFF episodes after they have been taking Levodopa for

9 years +9


Of young onset patients (less than 40 yrs old) develop OFF episodes after taking Levodopa for

5 years10

Problems with Oral Medications

Problems with Oral Medications

Oral medications containing levodopa are the most commonly prescribed treatment for Parkinson's disease and usually work quite well when first given. After some time you may start experiencing decreased "ON" time (when you are feeling your best), and may be having what are known as "OFF" episodes. These "OFF" episodes such as tremor, rigidity, slowness and difficulty moving happen when your Parkinson’s symptoms are at their worst. "OFF" episodes can interfere with your everyday work, recreation, or even routine daily activities for a few minutes up to a few hours. "OFF" episodes are fairly common in Parkinson’s and can happen at any time. They can occur as your Levodopa medications start to wear-off. This can happen first thing in the morning prior to your first dose of Levodopa medications or before it’s time to take your next dose. Some people experience multiple "OFF" episodes every day.


APOSAN® helps to reduce the amount of time spent in an "OFF" or immobile state in people who have been previously treated for Parkinson's disease with Levodopa and/or other dopamine agonists. APOSAN® can help you start your morning and your day. Clinical data shows that patients with morning "OFF" episodes will have rapid and reliable turning "ON" after APOSAN® Injection.


9. Frequency of Levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. https://www.ncbi.nlm.nih.gov/pubmed/11391738.

10. Young onset Parkinson's disease https://www.ncbi.nlm.nih.gov/pubmed/3504266

Aposan has helped many more to get them On. We would love to hear your story.

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