Why pump?

As Parkinson’s disease progresses, the Dopamine storage in the brain becomes increasingly compromised narrowing the therapeutic window for therapy and leading to motor fluctuations. APOSAN^® pump is a continuous, subcutaneous infusion of Apomorphine that bypasses the dysfunctional Gastrointestinal (GI) tract to distribute a continuous, accurate concentration of Dopamine receptor stimulation, for a continuous, reliable "ON".

GI tract complications are also very common in Parkinson’s disease. As oral medications are inherently dependent on the GI tract for absorption before being transported to their site of action, gastroparesis has been associated with response fluctuations with Levodopa therapy, further increasing the difficulty of trying to control motor fluctuations.

• APOSAN^® pump avoids the gastrointestinal tract, thus providing a reliable onset of clinical effects and achieve sustained control of plasma drug levels
• APOSAN^® pump provides significant progresses in quality of life (QOL) for PD patients
• APOSAN^® pump provides patients with Continuous Dopaminergic Stimulation (CDS) therapy, without the need for invasive surgical intervention
• APOSAN^® pump escapes the peaks and troughs of pulsatile Levodopa administration and widens the therapeutic window